Research Article | Open Access
Volume 2026 - 2 | Article ID 306 | http://dx.doi.org/10.51521/JORCR.2026/e2-1.106
Academic Editor: John Bose
Fatima Ezzohra ELHANAFI, Khadija Saadi, Sara OUASSIL, Meriem ELBAZ
Pediatric Hematology and Oncology Department, Mohammed VI University
Hospital, Marrakech
Faculty of Medicine and Pharmacy, Marrakech
Research Laboratory for Childhood, Health, and Sustainable Development,
Cadi Ayyad University
Corresponding Author: Fatima Ezzohra ELHANAFI, Pediatric Hematology, &
Oncology Department, Mohammed VI University Hospital, Marrakech, Email:
fz.elhanafi@gmail.com
Citation: Fatima Ezzohra ELHANAFI, Khadija Saadi, Sara OUASSIL, Meriem
ELBAZ, (2026). Subcutaneous Nodules Revealing Acute Lymphoblastic Leukemia in
an Infant: A Case Report and Literature Review. J Oncol Res Case Rep. 2(1),1-3.
Copyright: © 2026, Fatima Ezzohra ELHANAFI, et al., This is an open-access
article distributed under the terms of the Creative Commons Attribution 4.0
International License, which permits unrestricted use, distribution and
reproduction in any medium, provided the original author and source are
credited.
Abstract
Introduction: Osteosarcoma is the most common primary malignant bone tumor in adolescents. Metastasis most commonly involves the lungs and bones. Pancreatic metastasis is extremely uncommon and usually occurs in advanced stages. We report an exceptional case of femoral osteosarcoma with pancreatic metastases present at the time of diagnosis. Case Presentation: A 14-year-old female was admitted in February 2024 for a painful swelling of the left thigh and deterioration of general condition, accompanied by cholestatic jaundice. MRI showed a large left femoral tumor mass (65 × 56 × 219 mm) infiltrating surrounding soft tissues. Staging investigations identified a pancreatic tumor process causing biliary dilatation, along with pulmonary nodules and lytic bone lesions, suggesting metastatic dissemination at diagnosis. Bone biopsy confirmed a high-grade osteosarcoma. The patient received chemotherapy, which resulted in partial tumor regression. Surgery was not feasible. Despite a second-line chemotherapy regimen, the clinical course was unfavorable, marked by metastatic progression, spinal cord compression, and death in November 2024. Conclusion: This case illustrates an atypical presentation of osteosarcoma with pancreatic metastases evident from the time of diagnosis. This inaugural localization highlights the highly aggressive nature of the tumor and emphasizes the need for comprehensive abdominal staging, even at the early stages of management.
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